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Volume 6, Issue 5, September 2017, Page: 187-193
Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice
Mohammad Farhadur Rahman, Department of Chemistry, Bangladesh University of Textiles, Dhaka, Bangladesh
Nargish Jahan Ara, Department of Chemistry, Bangladesh University of Textiles, Dhaka, Bangladesh
Mohammad Mesbah Uddin, Department of Clinical Pathology, Dhaka Medical College, Dhaka, Bangladesh
Mohammad Zakir Sultan, Centre for Advanced Research in Sciences, University of Dhaka, Dhaka, Bangladesh
Received: Jun. 18, 2017;       Accepted: Jul. 5, 2017;       Published: Jul. 31, 2017
DOI: 10.11648/j.ijnfs.20170605.11      View  3775      Downloads  241
Abstract
The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.
Keywords
In Vivo, Reactive Dyes, Levafix Blue CA, Levafix Amber CA, Toxicity
To cite this article
Mohammad Farhadur Rahman, Nargish Jahan Ara, Mohammad Mesbah Uddin, Mohammad Zakir Sultan, Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice, International Journal of Nutrition and Food Sciences. Vol. 6, No. 5, 2017, pp. 187-193. doi: 10.11648/j.ijnfs.20170605.11
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Rahman, MA, Sultan MZ, Rahman MS, and Rashid MA. Food Adulteration: A Serious Public Health Concern in Bangladesh. Bangladesh Pharm J. 2014; 18(1): 1-7.
[2]
Bahari ifterer somahar. The Daily Amader Somoy, (A daily newspaper of Bangladesh), 1 July 2014.
[3]
Enforce existing laws against food adulteration. The Daily Observer. 22 June 2014.
[4]
Borzelleca JF and Hallogen JB. Life time toxicity/Carcinogenicity Study of FD & C Red No. 3 in mice. J FD Chem Toxicol. 1987; 25: 735.
[5]
Rahman SM, Hoque MA and Talukder MRA. Food security in Bangladesh: utilization, nutrition and food adulteration (paper presented at the National Workshop on Food security, Dhaka, Bangladesh, 19–20 October 2005), 2005; pp. 45-46.
[6]
Derek, L. Eight toxic foods: a little chemical education. In The Pipeline. 21 June, 2013.
[7]
Przystas W, Zablocka-Godlewska E, Grabinska-Sota E. Biological Removal of Azo and Triphenylmethane Dyes and Toxicity of Process By-Products. Water Air Soil Pollut. 2012; 223 (4): 1581-1592.
[8]
Sen S, Demirer GN. Anaerobic treatment of real textile wastewater with a fluidized bed reactor. Water Research. 2003; 37 (8): 1868-1878.
[9]
Zollinger, H. Synthesis, Properties of Organic Dyes and Pigments. In: Color Chemistry. New York, USA: VCH Publishers. 1987; p. 92-102.
[10]
Ogubue CJ, Sawidis T. Bioremediation and Detoxification of Synthetic Wastewater containing Triarylmethane Dyes by Aeromonas hydrophila Isolated from Industrial Effluent. Biotechnology Research International. 2011; DOI 10.4061/2011/967925.
[11]
Couto SR. Dye removal by immobolosed fungi. Biotechnology Advances. 2009; 27 (3): 221-235.
[12]
O’Neill C, Hawkes FR, Hawkes DL, Lourenco ND, Pinheiro HM, Delee W. Colour in textile effluents-sources, measurement, discharge consents and simulation: a reviews Journal of Chemical Technology and Biotechnology. 1999; 74 (11): 1009-1018.
[13]
Pearce CI, Lloyd JR, Guthrie JT. The removal of colour from textile wastewater using whole bacterial cells: a review. Dyes Pigments. 2003; 58:179-196.
[14]
Ozacar M and Singel A. Adsorption of metal complex dyes from aqueous solutions by pine sawdust. Bioresour. Technol. 2005; 96:791-795.
[15]
Baughman GL and Perenich TA. Fate of dyes in aquatic systems: I. Solubility and partitioning of some hydrophobic dyes and related compounds. Environ. Toxico. Chem.1988; 7:183-199.
[16]
Olukanni OD, Osuntoki AA, Gbenle GD. Textile effluent biodegradation potentials of textile effluent-adopted and nonadopted bacteria. Appl Environ Microbiol. 2005; 5(20):837-844.
[17]
Mahmoud NH. Toxic effects of the synthetic food dye brilliant blue on liver, kidney and tests functions in rats. J Egypt Soc Toxicol. 2006; 34: 77-84.
[18]
Wroblewski F and LaDue JS. Serum glutamic-pyruvic transminase in cardiac and hepatic disease. Proc Soc Exp Biol Med. 1956; 91:569-571.
[19]
Bergmeyer HU, Bowers GN Jr, Horder M, Moss DW. Provisional recommendations on IFCC methods for the measurement of catalytic concentrations of enzymes. Part 2. IFCC method for aspartate aminotransferase. Clin Chim Acta. 1976; 70(2):F 19-29.
[20]
Bergmeyer HU, Horder M. IFCC methods for the measurement of catalytic concentration of enzymes. Part 3 IFCC method for alanine aminotransferase. J Clin Chem Clin Biochem. 1980; 18:521-534.
[21]
Doumas BT, Kwok-Cheung PP, Perry BW, Jendrzejczak B, McComb RB, Schaffer R, Hause LL. Candidate reference method for determination of total bilirubin in serum: development and validation. Clin Chem. 1985; 31(11):1779-1789.
[22]
Jendrassik L, Grof P. Vereinfachte photometrische method zur bestimmung des bilirubins. Biochem Z. 1938; 297: 81-89.
[23]
Larsen K. Creatinine assay by a reaction-kinetic principle. Clin Chim Acta 1972; 41: 209-217.
[24]
Ibrahim NY, El-Desoky GE, Ramadan ME and El-Gendi SH. Comparative studies on the effect of some natural and synthetic food colorants on blood glucose and liver glycogen as well as glutamic aminotransferase in rats. Menia J Agric Res Rev. 1988, 10:16-59.
[25]
Mackenzie KM, Boysea BG, Field WE, Petsel SR, Chappel CL, Emerson JL and Stanley J. Toxicity of carcinogenicity studies of caramel color in F 344 rats and B 6 C 3 F-1 mice. Food Chem Toxicol. 1992; 30(5): 431-443.
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