Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms

Rufus Ojo Akomolafe; Olusoji Adeola Adalumo; Kayode Dominion Samuel Bamitale

doi:doi:10.11648/j.ajls.20140206.22

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Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms

Rufus Ojo Akomolafe, Olusoji Adeola Adalumo, Kayode Dominion Samuel Bamitale

Published in American Journal of Life Sciences (Volume 2, Issue 6)

Received: 11 November 2014 Accepted: 25 November 2014 Published: 6 January 2015

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Abstract

This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT3 & D2 blocker/5HT4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT3 and 5HT4 serotonergic and dopaminergic receptors.

Published in	American Journal of Life Sciences (Volume 2, Issue 6)
DOI	10.11648/j.ajls.20140206.22
Page(s)	406-412
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Zinc Acetate, Gastrointestinal Propulsion, Serotonergic Receptors and Transit Time

References

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Rufus Ojo Akomolafe, Olusoji Adeola Adalumo, Kayode Dominion Samuel Bamitale. (2015). Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. American Journal of Life Sciences, 2(6), 406-412. https://doi.org/10.11648/j.ajls.20140206.22

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Rufus Ojo Akomolafe; Olusoji Adeola Adalumo; Kayode Dominion Samuel Bamitale. Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. Am. J. Life Sci. 2015, 2(6), 406-412. doi: 10.11648/j.ajls.20140206.22

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AMA Style

Rufus Ojo Akomolafe, Olusoji Adeola Adalumo, Kayode Dominion Samuel Bamitale. Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. Am J Life Sci. 2015;2(6):406-412. doi: 10.11648/j.ajls.20140206.22

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@article{10.11648/j.ajls.20140206.22,
  author = {Rufus Ojo Akomolafe and Olusoji Adeola Adalumo and Kayode Dominion Samuel Bamitale},
  title = {Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms},
  journal = {American Journal of Life Sciences},
  volume = {2},
  number = {6},
  pages = {406-412},
  doi = {10.11648/j.ajls.20140206.22},
  url = {https://doi.org/10.11648/j.ajls.20140206.22},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140206.22},
  abstract = {This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT3 & D2 blocker/5HT4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT3 and 5HT4 serotonergic and dopaminergic receptors.},
 year = {2015}
}

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TY  - JOUR
T1  - Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms
AU  - Rufus Ojo Akomolafe
AU  - Olusoji Adeola Adalumo
AU  - Kayode Dominion Samuel Bamitale
Y1  - 2015/01/06
PY  - 2015
N1  - https://doi.org/10.11648/j.ajls.20140206.22
DO  - 10.11648/j.ajls.20140206.22
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 406
EP  - 412
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20140206.22
AB  - This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT3 & D2 blocker/5HT4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT3 and 5HT4 serotonergic and dopaminergic receptors.
VL  - 2
IS  - 6
ER  -

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Author Information

Rufus Ojo Akomolafe

Department of Physiological Sciences/Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun-State Nigeria
Olusoji Adeola Adalumo

Department of Physiological Sciences/Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun-State Nigeria
Kayode Dominion Samuel Bamitale

Department of Medical Pharmacology and Therapeutics/Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun-State Nigeria

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Rufus Ojo Akomolafe, Olusoji Adeola Adalumo, Kayode Dominion Samuel Bamitale. (2015). Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. American Journal of Life Sciences, 2(6), 406-412. https://doi.org/10.11648/j.ajls.20140206.22

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ACS Style

Rufus Ojo Akomolafe; Olusoji Adeola Adalumo; Kayode Dominion Samuel Bamitale. Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. Am. J. Life Sci. 2015, 2(6), 406-412. doi: 10.11648/j.ajls.20140206.22

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AMA Style

Rufus Ojo Akomolafe, Olusoji Adeola Adalumo, Kayode Dominion Samuel Bamitale. Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. Am J Life Sci. 2015;2(6):406-412. doi: 10.11648/j.ajls.20140206.22

Copy | Download

@article{10.11648/j.ajls.20140206.22,
  author = {Rufus Ojo Akomolafe and Olusoji Adeola Adalumo and Kayode Dominion Samuel Bamitale},
  title = {Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms},
  journal = {American Journal of Life Sciences},
  volume = {2},
  number = {6},
  pages = {406-412},
  doi = {10.11648/j.ajls.20140206.22},
  url = {https://doi.org/10.11648/j.ajls.20140206.22},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140206.22},
  abstract = {This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT3 & D2 blocker/5HT4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT3 and 5HT4 serotonergic and dopaminergic receptors.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms
AU  - Rufus Ojo Akomolafe
AU  - Olusoji Adeola Adalumo
AU  - Kayode Dominion Samuel Bamitale
Y1  - 2015/01/06
PY  - 2015
N1  - https://doi.org/10.11648/j.ajls.20140206.22
DO  - 10.11648/j.ajls.20140206.22
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 406
EP  - 412
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20140206.22
AB  - This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT3 & D2 blocker/5HT4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT3 and 5HT4 serotonergic and dopaminergic receptors.
VL  - 2
IS  - 6
ER  -

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