The sheathless particle focusing in a microchannel installing one set of multi-parallel channels or one porous orifice is proposed in this study. Numerical calculations have been carried out by the Lagrange two-phase model (i.e. the particle tracking model) in PHOENICS software for the microchannel including the porous orifice, in simulating both the channels installing the multi-parallel channels and the porous orifice. It becomes clear from calculation results that the particle focusing may be achieved at lower inlet velocities by using the porous orifice. Low velocities correspond to reduction in the sample flow including particles (i.e. cells). It also becomes obvious that the particle focusing is improved if the porous orifice with taper shape is used. Furthermore, particle focusing experiments have been conducted in the channel including the multi-parallel channels. It becomes clear that the particle focusing may be achieved by using the multi-parallel channels.
| Published in | International Journal of Mechanical Engineering and Applications (Volume 6, Issue 3) |
| DOI | 10.11648/j.ijmea.20180603.11 |
| Page(s) | 46-54 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Particle Focusing, Microchannel, Multi-Parallel Channels, Porous Orifice
| [1] | D. D. Carlo, “Critical review: Inertial microfluidics,” Lab on a Chip, vol. 9, pp. 3038–3046, 2009. |
| [2] | X. Xuan, J. Zhu, and C. Church, “Review: Particle focusing in microfluidic devices,” Microfluid Nanofluid, vol. 9, pp. 1-16, 2010. |
| [3] | J. M. Martel, and M. Toner, “Inertial Focusing in Microfluidics,” Annu Rev Biomed Eng., vol. 16, pp. 371-396, 2014. |
| [4] | N. Watkins, B. M. Venkatesan, M. Toner, W. Rodriguez, and R. Bashir, “A robust electrical microcytometer with 3-dimensional hydrofocusing,” Lab on a Chip, vol. 9, pp. 3177-3184, 2009. |
| [5] | X. Mao, S. C. S. Lin, C. Dong, and T. J. Huang, “Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing,” Lab on a Chip, vol. 9, pp. 1583-1589, 2009. |
| [6] | L. L. Fan, X. K. He, Y. Han, J. Zhe, and L. Zhao, “Continuous 3D particle focusing in a microchannel with curved and symmetrical sharp corner structures,” J. of Micromechanics and Microengineering, vol. 25, no. 3, 035021, 2015. |
| [7] | M. G. Lee, S. Choi, and J. K. Park, “Three-dimensional hydrodynamic focusing with a single sheath flow in a single-layer microfluidic device,” Lab on a Chip, vol. 9, pp. 3155-3160, 2009. |
| [8] | J. P. Golden, J. S. Kim, J. S. Erickson, L. R. Hilliard, P. B. Howell, G. P. Anderson et al., “Multi-wavelength microflow cytometer using groove-generated sheath flow,” Lab on a Chip, vol. 9, pp. 1942-1950, 2009. |
| [9] | N. Hashemi, P. B. Howell, J. S. Erickson, J. P. Golden, and F. S. Ligler, “Dynamic reversibility of hydrodynamic focusing for recycling sheath fluid,” Lab on a Chip, vol. 10, pp. 1952-1959, 2010. |
| [10] | T. Sato, and R. Miyake, “Sheath flow forming by using twisted micro-channel,” Transactions of The Japan Society of Mechanical Engineering (JSME), vol. 80, no. 813, pp. 1-11, 2014 [In Japanese]. |
| [11] | D. D. Carlo, J. F. Edd, D. Irimia, R. G. Tompkins, and M. Toner, “Equilibrium separation and filtration of particles using differential inertial focusing,” Analytical Chemistry, vol. 80, no. 6, pp. 2204-2211, 2008. |
| [12] | D. R. Gossett, and D. D. Carlo, “Particle focusing mechanisms in curving confined flows,” Analytical Chemistry, vol. 81, no. 20, pp. 8459-8465, 2009. |
| [13] | J. Oakey, R. W. Applegate, E. Arellano, D. D. Carlo, S. W. Graves and M. Toner, “Particle focusing in staged inertial microfluidic devices for flow cytometry,” Analytical Chemistry, vol. 82, no. 9, pp. 3862-3867, 2010. |
| [14] | J. M. Martel, and M. Toner, “Particle focusing in curved microfluidic channels,” Scientific Reports 3, 3340 (8 pages), 2013. |
| [15] | J. Zhang, W. Li, M. Li, G. Alici, and N. Nguyen, “Particle inertial focusing and its mechanism in a serpentine microchannel,” Microfluidics and Nanofluidics, vol. 17, no. 2, pp. 305-316, 2014. |
| [16] | A. Ozbey, M. Karimzadehkhouei, S. Akgonul, D. Gozuacik, and A. Kosar, “Inertial focusing of microparticles in curvilinear microchannels,” Scientific Reports 6, 38809 (11 pages), 2016. |
| [17] | D. Jiang, W. Tang, N. Xiang, and Z. Ni, “Numerical simulation of particle focusing in a symmetrical serpentine microchannel,” RSC Advances, vol. 6, issue 62, pp. 57647-57657, 2016. |
| [18] | P. Paie, F. Bragheri, D. D. Carlo, and R. Osellame, “Particle focusing by 3D inertial microfluidics,” Microsystem & Nanoengineering, vol. 3, 17027 (8 pages), 2017. |
| [19] | L. Wang, and D. S. Dandy, “High-throughput inertial focusing of micrometer- and sub-micrometer-sized particles separation,” Advanced Science, vol. 4, 1700153 (11 pages), 2017. |
| [20] | A. Shamloo, and A. Mashhadian, “Inertial particle focusing in serpentine channels on a centrifugal platform,” Physics of Fluids, vol. 30, no. 1, 012002, 2018. |
| [21] | J. A. Kim, J. R. Lee, T. J. Je, E. C. Jeon, and W. Lee, “Size-dependent inertial focusing position shift and particle separations in triangular microchannels,” Analytical Chemistry, vol. 90, no. 3, pp. 1827-1835, 2018. |
| [22] | J. S. Park, S. H. Song, and H. I. Jung, “Continuous focusing of microparticles using inertial lift force and velocity via multi-orifice microfluidic channels,” Lab on a Chip, vol. 9, pp. 939-948, 2009. |
| [23] | S. Choi, and J. K. Park, “Sheathless hydrophoretic particle focusing in a microchannel with exponentially increasing obstacle arrays,” Analytical Chemistry, vol. 80, no. 8, pp. 3035-3039, 2008. |
| [24] | http://www.cham.co.uk/ |
APA Style
Hiroshige Kumamaru, Hirofumi Sugami, Masaki Nakahira, Naohisa Takagaki. (2018). Particle Focusing in Microchannel with Multi-Parallel Channels or Porous Orifice. International Journal of Mechanical Engineering and Applications, 6(3), 46-54. https://doi.org/10.11648/j.ijmea.20180603.11
ACS Style
Hiroshige Kumamaru; Hirofumi Sugami; Masaki Nakahira; Naohisa Takagaki. Particle Focusing in Microchannel with Multi-Parallel Channels or Porous Orifice. Int. J. Mech. Eng. Appl. 2018, 6(3), 46-54. doi: 10.11648/j.ijmea.20180603.11
AMA Style
Hiroshige Kumamaru, Hirofumi Sugami, Masaki Nakahira, Naohisa Takagaki. Particle Focusing in Microchannel with Multi-Parallel Channels or Porous Orifice. Int J Mech Eng Appl. 2018;6(3):46-54. doi: 10.11648/j.ijmea.20180603.11
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Download@article{10.11648/j.ijmea.20180603.11,
author = {Hiroshige Kumamaru and Hirofumi Sugami and Masaki Nakahira and Naohisa Takagaki},
title = {Particle Focusing in Microchannel with Multi-Parallel Channels or Porous Orifice},
journal = {International Journal of Mechanical Engineering and Applications},
volume = {6},
number = {3},
pages = {46-54},
doi = {10.11648/j.ijmea.20180603.11},
url = {https://doi.org/10.11648/j.ijmea.20180603.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmea.20180603.11},
abstract = {The sheathless particle focusing in a microchannel installing one set of multi-parallel channels or one porous orifice is proposed in this study. Numerical calculations have been carried out by the Lagrange two-phase model (i.e. the particle tracking model) in PHOENICS software for the microchannel including the porous orifice, in simulating both the channels installing the multi-parallel channels and the porous orifice. It becomes clear from calculation results that the particle focusing may be achieved at lower inlet velocities by using the porous orifice. Low velocities correspond to reduction in the sample flow including particles (i.e. cells). It also becomes obvious that the particle focusing is improved if the porous orifice with taper shape is used. Furthermore, particle focusing experiments have been conducted in the channel including the multi-parallel channels. It becomes clear that the particle focusing may be achieved by using the multi-parallel channels.},
year = {2018}
}
TY - JOUR T1 - Particle Focusing in Microchannel with Multi-Parallel Channels or Porous Orifice AU - Hiroshige Kumamaru AU - Hirofumi Sugami AU - Masaki Nakahira AU - Naohisa Takagaki Y1 - 2018/05/28 PY - 2018 N1 - https://doi.org/10.11648/j.ijmea.20180603.11 DO - 10.11648/j.ijmea.20180603.11 T2 - International Journal of Mechanical Engineering and Applications JF - International Journal of Mechanical Engineering and Applications JO - International Journal of Mechanical Engineering and Applications SP - 46 EP - 54 PB - Science Publishing Group SN - 2330-0248 UR - https://doi.org/10.11648/j.ijmea.20180603.11 AB - The sheathless particle focusing in a microchannel installing one set of multi-parallel channels or one porous orifice is proposed in this study. Numerical calculations have been carried out by the Lagrange two-phase model (i.e. the particle tracking model) in PHOENICS software for the microchannel including the porous orifice, in simulating both the channels installing the multi-parallel channels and the porous orifice. It becomes clear from calculation results that the particle focusing may be achieved at lower inlet velocities by using the porous orifice. Low velocities correspond to reduction in the sample flow including particles (i.e. cells). It also becomes obvious that the particle focusing is improved if the porous orifice with taper shape is used. Furthermore, particle focusing experiments have been conducted in the channel including the multi-parallel channels. It becomes clear that the particle focusing may be achieved by using the multi-parallel channels. VL - 6 IS - 3 ER -
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