Malnutrition in children is associated with signs of liver dysfunction such as hepatic steatosis, which increases morbidity and mortality. This research aims to study the epidemiological, clinical and paraclinical aspects of hepatic steatosis in malnourished children at the CNHU-HKM and CHU-MEL of Cotonou. This was a descriptive and analytical cross-sectional study that took place from May 1 to July 31, 2017. Malnourished children aged 06 months to 05 years old who were hospitalized or received outpatient care during the study period were included. An exhaustive sampling of all children meeting the eligibility criteria during the study period was conducted. Ninety-four malnourished children were included in the study. Their mean age was 18.47 months. The hospital prevalence of hepatic steatosis was 60.6%. Hepatic steatosis was diffuse and homogeneous without focal lesions. Clinically, it was significantly associated with hepatomegaly, underweight and severe chronic malnutrition. A statistically significant association was also observed between, respectively, non-supplementation with iron/folic acid, recent non-adherence to EPI vaccines and hepatic steatosis. Biologically, there was a statistically significant association between hepatic steatosis and transaminases, gamma GT, triglycerides, albuminemia. Hepatic steatosis is common in malnourished children. There is a clinico-biological correlation. Liver ultrasound should be systematic in cases of malnutrition.
| Published in | International Journal of Nutrition and Food Sciences (Volume 10, Issue 6) |
| DOI | 10.11648/j.ijnfs.20211006.12 |
| Page(s) | 126-133 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Hepatic Steatosis, Malnutrition, Associated Factors, Benin
| [1] | World Health Organization. Malnutrition [Internet]. [cited 24 Oct 2020]. Available at: https://www.who.int/fr/news-room/fact-sheets/detail/malnutrition |
| [2] | Di Sessa A, Umano GR, Miraglia del Giudice E, Santoro N. From the liver to the heart: Cardiac dysfunction in obese children with non-alcoholic fatty liver disease. World J Hepatol. 2017; 9 (2): 69-73. |
| [3] | Clemente MG, Mandato C, Poeta M, Vajro P. Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions. World J Gastroenterol. 2016; 22 (36): 8078-93. |
| [4] | Oh RC, Hustead TR, Ali SM, Pantsari MW. Mildly Elevated Liver Transaminase Levels: Causes and Evaluation. Am Fam Physician. 2017; 96 (11): 709-715. |
| [5] | Doherty JF, Adam EJ, Griffin GE, Golden MH. Ultrasonographic assessment of the extent of hepatic steatosis in severe malnutrition. Arch Dis Child. 1992; 67 (11): 1348-52. |
| [6] | Badaloo AV, Forrester T, Reid M, Jahoor F. Lipid kinetic differences between children with kwashiorkor and those with marasmus. Am J Clin Nutr. 2006; 83 (6): 1283-8. |
| [7] | Truswell AS, Miller JC. Pathogenesis of the fatty liver in protein energy malnutrition. Am J Clin Nutr. 1993; 57 (5): 695-6. |
| [8] | Lalwani SG, Karande S, Khemani R, Jain MK. Ultrasonographic evaluation of hepatic steatosis in malnutrition. Indian Pediatr. 1998; 35 (7): 650-2. |
| [9] | Van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, et al. Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol. 2016; 65 (6): 1198-208. |
| [10] | Coussement A, Faure C. Repères et mesures en imagerie médicale. 4th ed. Paris: Expansion Scientifique Française; 1990. |
| [11] | Iijima H, Moriyasu F, Tsuchiya K. Decrease in accumulation of ultrasound contrast microbubbles in non-alcoholic steatohepatitis. Hepatol Res. 2007; 37: 722-30. |
| [12] | Pacifico L, Poggiogalle E, Cantisani V, Menichini G, Ricci P, Ferraro F, et al. Pediatric nonalcoholic fatty liver disease: A clinical and laboratory challenge. World J Hepatol. 2010; 2 (7): 275-88. |
| [13] | Alisi A, Feldstein AE, Villani A, Raponi M, Nobili V. Pediatric nonalcoholic fatty liver disease: a multidisciplinary approach. Nat Rev Gastroenterol Hepatol. 2012; 9 (3): 152-61. |
| [14] | Shannon A, Alkhouri N, Carter-Kent C, Monti L, Devito R, Lopez R, et al. Ultrasonographic Quantitative Estimation of Hepatic Steatosis in Children with Nonalcoholic Fatty Liver Disease (NAFLD). J Pediatr Gastroenterol Nutr. 2011; 53 (2): 190-5. |
| [15] | Özcan HN, Oğuz B, Haliloğlu M, Orhan D, Karçaaltıncaba M. Imaging patterns of fatty liver in pediatric patients. Diagn Interv Radiol. 2015 Jul-Aug; 21 (4): 355-60. |
| [16] | Song P, Yu J, Wang M, Chang X, Wang J, An L. Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children. Int J Environ Res Public Health. 2017; 14 (5): 465. |
| [17] | Vajro P, Lenta S, Socha P, Dhawan A, McKiernan P, Baumann U, et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr. 2012; 54 (5): 700-13. |
| [18] | Hourigan SK, Torbenson M, Tibesar E, Scheimann AO. The full spectrum of hepatic steatosis in children. Clin Pediatr (Phila). 2015; 54 (7): 635-42. |
| [19] | Ahmed U, Latham PS, Oates PS. Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis. World J Gastroenterol. 2012; 18 (34): 4651-8. |
| [20] | Sherman AR. Lipogenesis in iron-deficient adult rats. Lipids. 1978; 13 (7): 473-8. |
| [21] | Sherman AR, Bartholmey SJ, Perkins EG. Fatty acid patterns in iron-deficient maternal and neonatal rats. Lipids. 1982; 17 (9): 639-43. |
| [22] | Bartholmey SJ, Sherman AR. Carnitine levels in iron-deficient rat pups. J Nutr. janv 1985; 115 (1): 138-45. |
| [23] | Hulse JD, Ellis SR, Henderson LM. Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase. J Biol Chem. 1978; 253 (5): 1654-9. |
| [24] | Davis MR, Rendina E, Peterson SK, Lucas EA, Smith BJ, Clarke SL. Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency. Genes Nutr. 2012; 7 (3): 415-25. |
| [25] | Cruz MAF, Cruz JF, Macena LB, de Santana DS, Oliveira CC da C, Lima SO, et al. Association of the Nonalcoholic Hepatic Steatosis and Its Degrees with the Values of Liver Enzymes and Homeostasis Model Assessment-Insulin Resistance Index. Gastroenterology Res. 2015; 8 (5): 260-4. |
| [26] | Preidis GA, Keaton MA, Campeau PM, Bessard BC, Conner ME, Hotez PJ. The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress. J Nutr. 2014; 144 (3): 273-81. |
| [27] | Truswell AS, Hansen JD. Fatty liver in protein-calorie malnutrition. South African Medical Journal. 1969; 43 (10): 280-3. |
| [28] | Truswell AS. Carbohydrate and lipid metabolism in protein-calorie malnutrition. In: Olson RE, editor. Protein Calorie Malnutrition. Cambridge: Academic Press. 1975. p. 119-41. |
| [29] | Badaloo AV, Forrester T, Reid M, Jahoor F. Nutritional Repletion of Children with Severe Acute Malnutrition Does Not Affect VLDL Apolipoprotein B-100 Synthesis Rate 12. J Nutr. 2012; 142 (5): 931-5. |
APA Style
Florence Alihonou, Patricia Yekpe, Francis Honnorat Lalya, Mohammed Dakin, Marcelline D’Almeida Hounnou, et al. (2021). Hepatic Steatosis and Radiological, Clinical and Biological Correlation in Malnourished Children in Two Referral Hospitals in Cotonou. International Journal of Nutrition and Food Sciences, 10(6), 126-133. https://doi.org/10.11648/j.ijnfs.20211006.12
ACS Style
Florence Alihonou; Patricia Yekpe; Francis Honnorat Lalya; Mohammed Dakin; Marcelline D’Almeida Hounnou, et al. Hepatic Steatosis and Radiological, Clinical and Biological Correlation in Malnourished Children in Two Referral Hospitals in Cotonou. Int. J. Nutr. Food Sci. 2021, 10(6), 126-133. doi: 10.11648/j.ijnfs.20211006.12
AMA Style
Florence Alihonou, Patricia Yekpe, Francis Honnorat Lalya, Mohammed Dakin, Marcelline D’Almeida Hounnou, et al. Hepatic Steatosis and Radiological, Clinical and Biological Correlation in Malnourished Children in Two Referral Hospitals in Cotonou. Int J Nutr Food Sci. 2021;10(6):126-133. doi: 10.11648/j.ijnfs.20211006.12
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ijnfs.20211006.12,
author = {Florence Alihonou and Patricia Yekpe and Francis Honnorat Lalya and Mohammed Dakin and Marcelline D’Almeida Hounnou and Olivier Biaou},
title = {Hepatic Steatosis and Radiological, Clinical and Biological Correlation in Malnourished Children in Two Referral Hospitals in Cotonou},
journal = {International Journal of Nutrition and Food Sciences},
volume = {10},
number = {6},
pages = {126-133},
doi = {10.11648/j.ijnfs.20211006.12},
url = {https://doi.org/10.11648/j.ijnfs.20211006.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20211006.12},
abstract = {Malnutrition in children is associated with signs of liver dysfunction such as hepatic steatosis, which increases morbidity and mortality. This research aims to study the epidemiological, clinical and paraclinical aspects of hepatic steatosis in malnourished children at the CNHU-HKM and CHU-MEL of Cotonou. This was a descriptive and analytical cross-sectional study that took place from May 1 to July 31, 2017. Malnourished children aged 06 months to 05 years old who were hospitalized or received outpatient care during the study period were included. An exhaustive sampling of all children meeting the eligibility criteria during the study period was conducted. Ninety-four malnourished children were included in the study. Their mean age was 18.47 months. The hospital prevalence of hepatic steatosis was 60.6%. Hepatic steatosis was diffuse and homogeneous without focal lesions. Clinically, it was significantly associated with hepatomegaly, underweight and severe chronic malnutrition. A statistically significant association was also observed between, respectively, non-supplementation with iron/folic acid, recent non-adherence to EPI vaccines and hepatic steatosis. Biologically, there was a statistically significant association between hepatic steatosis and transaminases, gamma GT, triglycerides, albuminemia. Hepatic steatosis is common in malnourished children. There is a clinico-biological correlation. Liver ultrasound should be systematic in cases of malnutrition.},
year = {2021}
}
TY - JOUR T1 - Hepatic Steatosis and Radiological, Clinical and Biological Correlation in Malnourished Children in Two Referral Hospitals in Cotonou AU - Florence Alihonou AU - Patricia Yekpe AU - Francis Honnorat Lalya AU - Mohammed Dakin AU - Marcelline D’Almeida Hounnou AU - Olivier Biaou Y1 - 2021/11/23 PY - 2021 N1 - https://doi.org/10.11648/j.ijnfs.20211006.12 DO - 10.11648/j.ijnfs.20211006.12 T2 - International Journal of Nutrition and Food Sciences JF - International Journal of Nutrition and Food Sciences JO - International Journal of Nutrition and Food Sciences SP - 126 EP - 133 PB - Science Publishing Group SN - 2327-2716 UR - https://doi.org/10.11648/j.ijnfs.20211006.12 AB - Malnutrition in children is associated with signs of liver dysfunction such as hepatic steatosis, which increases morbidity and mortality. This research aims to study the epidemiological, clinical and paraclinical aspects of hepatic steatosis in malnourished children at the CNHU-HKM and CHU-MEL of Cotonou. This was a descriptive and analytical cross-sectional study that took place from May 1 to July 31, 2017. Malnourished children aged 06 months to 05 years old who were hospitalized or received outpatient care during the study period were included. An exhaustive sampling of all children meeting the eligibility criteria during the study period was conducted. Ninety-four malnourished children were included in the study. Their mean age was 18.47 months. The hospital prevalence of hepatic steatosis was 60.6%. Hepatic steatosis was diffuse and homogeneous without focal lesions. Clinically, it was significantly associated with hepatomegaly, underweight and severe chronic malnutrition. A statistically significant association was also observed between, respectively, non-supplementation with iron/folic acid, recent non-adherence to EPI vaccines and hepatic steatosis. Biologically, there was a statistically significant association between hepatic steatosis and transaminases, gamma GT, triglycerides, albuminemia. Hepatic steatosis is common in malnourished children. There is a clinico-biological correlation. Liver ultrasound should be systematic in cases of malnutrition. VL - 10 IS - 6 ER -
Email: